Targeting pituitary adenylate cyclase–activating polypeptide (PACAP) is a new avenue for treating migraine. The efficacy and safety of intravenous Lu AG09222, a humanized monoclonal antibody ...

Migraine is a heterogeneous disorder, so the selection of initial treatment for acute attacks depends on the severity and frequency of the attacks, the associated symptoms, the preference of the ...

Calcitonin gene–related peptide (CGRP) plays a role in the pathophysiological features of migraine, 10-12 and small-molecule CGRP receptor antagonists (gepants) have been shown to be effective ...

Snow, V, Weiss, K, Wall, EM, Mottur-Pilson, C. Pharmacologic management of acute attacks of migraine and prevention of migraine headache. Ann Intern Med 2002;137:840-849 Crossref ...

Patients with transformed migraine most often overuse acute-headache medications such as analgesics ... New England Journal of Medicine. Volume 354 • Number 2 • January 12, 2006. Pages: 158-165.

Acute migraine–specific medications, such as the serotonin 5-HT 1B and 5-HT 1D receptor agonists ... New England Journal of Medicine. Volume 377 • Number 22 • November 30, 2017. Pages: 2123 ...

Familial hemiplegic migraine is genetically heterogeneous. 12,13,17,18 CACNA1A, the first gene that has been associated with the disorder, is located on chromosome 19 and encodes the α 1A subunit ...

Which medication, if any, to use to prevent the headache of pediatric migraine has not been established.We conducted a randomized, double-blind, placebo-controlled trial of amitriptyline (1 mg per ...

Focusing on acute and preventive therapies for migraines, this Double Take video discusses pathophysiology and provides practical treatment information for this common condition.

To the Editor: In their review of the treatment of migraine, Goadsby et al. (Jan. 24 issue)1 did not mention the importance of caffeine in inducing migraine attacks and thwarting treatment efforts ...

Therapy of the Acute AttackGeneral PrinciplesWolff16 has suggested that the migraine experience serves a biologic ... New England Journal of Medicine. Volume 253 • Number 18 • November 3, 1955 ...

Recent developments in the knowledge of the local physiologic changes that occur in migraine, ... New England Journal of Medicine. Volume 265 • Number 21 • November 23, 1961. Pages: 1054-1057.