Centromeres, specialized regions located at the center of chromosomes, are critical for ensuring proper cell division. During ...

Mutation of Lis1, a key dynein regulator, can lead to the rare mental developmental disorder lissencephaly, or “smooth brain, ...

SNL described the picture saying that an engineer is making “connections on the first B61-13 joint test assembly,” referring to the orange-colored unit on the trolley. The weapon appears ...

assembly dynamics, and lattice defects at submolecular resolution under physiological conditions. Figure 1. High-resolution AFM image of the inner and outer surfaces of a microtubule. (Image: Nano ...

The γ-tubulin ring complex (γ-TuRC) is a structural template for de novo microtubule assembly from α/β-tubulin units. The isolated vertebrate γ-TuRC assumes an asymmetric, open structure deviating ...

Previous work suggests that the female hormone estrogen disrupts microtubule assembly. Here, we explored whether estrogen treatment could ameliorate the pathological proliferation of microtubules. By ...

Researchers led by Dr. Jens Lüders at IRB Barcelona have discovered a key role played by the ch-TOG protein in the initiation of microtubule assembly during the interphase stage of the cell cycle ...

The major microtubule-organizing center (MTOC) in animal cells, the centrosome, comprises a pair of centrioles surrounded by pericentriolar material (PCM), which nucleates and anchors microtubules.

Nucleation is mediated by the γ-tubulin ring complex (γTuRC), which, in cooperation with its recruitment and activation factors, provides a template for α- and β-tubulin assembly, facilitating ...

Our results shed light on the molecular components and functional understanding of the SDA hierarchical assembly and microtubule organization. The subdistal appendage (SDA) is a distinct structure of ...

The centrosome, which nucleates microtubules and branched actin, appears to be a privileged site for WASH complex assembly. The actin and microtubule cytoskeletons are both responsible for endosome ...