Mutation of Lis1, a key dynein regulator, can lead to the rare mental developmental disorder lissencephaly, or “smooth brain, ...

thus increasing the free energy barrier that needs to be overcome to form a straight microtubule lattice. Electron Tomography Confirms Predicted Structural Differences at the Ends of Growing and ...

This step of actin assembly/disassembly is followed by the addition of tubulin to measure again centrosome nucleation capacity. The amount of microtubule per centrosome is compared between the first ...

Both impaired actin reorganization and attenuated microtubule filament formation inhibit cancer cell migration and invasion, thereby preventing metastasis. On the other hand, failure of spindle ...

Centromeres, specialized regions located at the center of chromosomes, are critical for ensuring proper cell division. During ...

BACKGROUND: Dilated cardiomyopathy (DCM) is substantially influenced by genetic factors. Sarcomere function is intricately associated with other organelles, particularly the reciprocal regulation ...

Motor motion on cytoskeletal filaments is particularly important for biological length regulation, because numerous proteins targeted to microtubule ends modify their dynamics and can dramatically ...

This study will be of interest to the breast cancer field. Microtubule-targeting agents (MTAs) are widely used as first- and second-line chemotherapies for various cancers. However, current MTAs ...

Brief ciprofloxacin exposure in humans drives antibiotic resistance evolution in gut bacteria through selective sweeps, particularly involving DNA gyrase mutations, which persist long after ...