A cocktail of FDA-approved cancer drugs, trametinib and rapamycin, boosts the lifespan of lab mice by 30% and might help ...

In a new study out this week, scientists report that a combination of two existing cancer drugs — rapamycin and trametinib — ...

Compared with controls, treated mice exhibited lower liver weight, reduced plasma alanine transaminase and aspartate transaminase levels, and decreased hepatic triglyceride and total cholesterol.

Using semaglutide injections, scientists were able to reverse life-threatening cases of liver disease in a new clinical trial published in The New England Journal of Medicine. Semaglutide ...

Histamine and mast cells have been implicated in liver pathology ... models of EPP- the Ferrochelatase mutant 1 with a pedigree from Pas (Fechm1Pas) mice and mice fed with a porphyrinogenic ...

IMT treatment significantly reduced hepatosteatosis in HFD-fed mice, accompanied by decreased liver lipid content and weight. A reversal of diglyceride and triglyceride accumulation was observed ...

Mutant mice also exhibited abnormal circadian rhythms during hypoactivity episodes. Circadian rhythm is the cyclical pattern of physiological changes that normally coincides with daytime and night ...

In this study, the role of NLRP3 activation in neutrophils during liver inflammation and fibrosis was investigated. Mouse models with neutrophil‐specific expression of mutant NLRP3 were developed.

Researchers from the University of Michigan (U-M) Life Sciences Institute report they have discovered a hormone secreted by fat cells can restrain the growth of liver tumors in mice. The findings ...

In fact, mice with p53 accumulation did have increased liver tumor development. Increased liver carcinogenesis by p53 activation in hepatocyte-specific Kras-mutant mice and the tumor-suppressive ...

induces Gpx4 gene expression in vivo Gpx4 protein was measured in liver of WT and PPARα −/− mice fed blank solvent or GW7647; n = 4 biological replicates. C. Schematic of the WT and mutant PPRE ...