TM6SF2 GKO mice fed an HFD showed elevated liver and intestinal lipid deposition compared to CON mice. The gut microbiota of HFD-fed TM6SF2 GKO mice exhibited a decreased Firmicutes/Bacteroidetes ...

1997; Peier et al., 2002). In particular, genetically modified knockout (KO) mice models have emerged as powerful tools to explore TRP channel functions in cardiac tissue, allowing for precise ...

While the task measured cognitive flexibility in mice, it remains unknown whether the effects would translate to humans or to other types of cognitive flexibility beyond reversal learning. The study ...

Moreover, BAT-specific MICT1 ablation in mice suppresses thermogenic capacity to increase adiposity and insulin resistance. Conversely, MICT1 overexpression in BAT or treating mice with a chemical ...

While constitutive Cdk5 knockout is perinatally lethal, conditional knockout mice display resilience to stress-induction, enhanced cognition, neuroprotection from stroke and head trauma, and ...

The evidence for the authors' claims is convincing, combining state-of-the-art conditional gene deletion in the mouse lens with histological and molecular approaches. This work should be of great ...

Design We constructed a novel hepatocyte-specific PPARα knockout (Pparα hep−/−) mouse model. Using this novel model, we performed transcriptomic analysis following fenofibrate treatment. Next, we ...