A new way of thinking about Alzheimer's disease has yielded a discovery that could be the key to stopping the cognitive ...

Here, we present a versatile state-of-the-art toolbox including the preparation of protein:DNA complex samples, design of a microfluidic flow cell incorporated with OT, automation of OT-confocal ...

We introduce MADna, a sequence-dependent coarse-grained model of double-stranded DNA (dsDNA), where each nucleotide is described by three beads localized at the sugar, at the base moiety, and at the ...

Altogether, these features allow us to propose that the arm regions of the Smc5/6 complex are engaged in multiple protein–protein interactions, in addition to linking the head and hinge regions. As ...

We have identified a novel SCF complex‐interacting protein ... with the plasmid pLexA‐KM encoding the F‐box proteins Ydr131c, Yjl149w, Ydr306c, Ybr203w, or Ymr258c and with a budding yeast DNA library ...

The authors advance this technique by integrating peptide ligation technology and nanobody-based antibody mimetics - cost-effective and scalable alternatives to conventional antibodies - into a ...

More specifically, genes that encode the tumour-suppressor proteins BRCA1 and BRCA2 are ... 7,8 to show that the BRCA1–BARD1 complex binds DNA with a preference for branched DNA structures ...

By contrast, in a living cell DNA lives in a very crowded environment, and special proteins attach to DNA to mechanically unwind the double helix and then pry it apart. "The interior of the cell ...

Another benefit of the early access testing is the opportunity for Ansa to gauge the community’s appetite for long, complex DNA. “I want to understand how we are helping them,” Gammack told GEN.

Two proteins, TRF2 and RAP1 ... treat the natural ends of chromosomes as broken DNA and try to fix them. Formation of the TRF2–RAP1–DNA-PK complex prevents unwanted chromosome fusions and ...