MASITINIB SHOWS PROMISING NEUROPROTECTIVE EFFECTS IN NEUROIMMUNE-DRIVEN NEURODEGENERATIVE DISEASE MODEL . A NEW PUBLICATION IN THE SCIENTIFIC JOURNAL PLOS ONE, SHOW ...

In the retina, age-related macular degeneration (AMD ... circulating lymphocytes and monocytes/macrophages and mast cells. Stimulation of monocytes can lead to interleukin secretion and ...

Mast cell activation syndrome, or disease (MCAS), is a condition that causes mast cells to release these substances too frequently, resulting in severe allergic reactions. After detecting an ...

underscoring the importance of treating patients early in the ISM disease course -- -- BLU-808 healthy volunteer trial results demonstrate wide therapeutic window for modulating mast cell activity ...

"Our findings reinforce the crucial role of metal ions and oxidative stress in AMD and suggest that Telomir-1 could provide a breakthrough approach to protecting retinal cells from degeneration," said ...

Ultimately, her research led to mast cell activation syndrome, or MCAS, a condition in which mast cells (a type of white blood cell) overreact for reasons that aren’t always clear. These ...

Depending on one's perspective, "mast cell activation syndrome (MCAS)" is either a relatively rare, narrowly defined severe allergic condition or a vastly under-recognized underlying cause of ...

Age-related macular degeneration (AMD), a prevalent and progressive degenerative ... Special attention is given to the potential role of mast cells in CNV and subretinal fibrosis, with a focus on ...

Concurrent enhancer of Zeste homolog 2 (EZH2) over-expression with BRAFV600E mutation predicts a poor outcome in patients with Langerhans cell histiocytosis (LCH): A pilot study. A phase 1b/2 study of ...

Mast cell activation syndrome is a condition that causes mast cells to release an inappropriate amount of chemicals into your body. This causes allergy symptoms and a wide range of other symptoms.