the major and minor grooves. Small molecules and proteins can in principle bind in either; which is preferred is important for their subsequent effects on DNA function — as regulators of DNA ...

DNA has two kinds of grooves that play important roles in its functioning. Major and minor grooves help in formation of different proteins. These grooves bind proteins like transcription factors ...

To visualize how THAP proteins interact with specific DNA sequences, we determined the crystal structure of DmTHAP in complex with a naturally occurring 10-bp DNA site at 1.74-Å resolution by ...

With this method, they could see details that hadn’t previously been visible before, down to the characteristic major and minor grooves in the helix. “Rather than just seeing DNA as sort of a ...

B-DNA is the “Watson-Crick” form of DNA, which is in the form of a right-handed helix with a helical repeat (pitch) of ~3.6nm, with minor and major grooves of widths ~2.2nm and ~1.2nm, respectively.

In my animation, the DNA itself is also an accurate model, complete with structural details such as the major and minor groove, thermal or Brownian motion of atoms and 10.5 base pairs per 360 ...

These dual-labeled hydrolysis probes consist of a 5' fluorescent reporter dye and a 3' Eclipse Dark Quencher (EDQ) coupled to the minor groove binder ... purified (B) DNA gave clear clusters ...