Beneath the surface of present-day western Honduras lie the ruins of Copán—an archaeological site that once stood as a vital ...

The small study in patients with a rare disorder that causes liver and lung damage showed the potential for precisely targeted infusions. By Gina Kolata Researchers have corrected a disease ...

The role of microhydration in structural adjustments of the AT-tract in B-DNA was studied at the B97-D/def2-SV(P) level. The (dA:dT) 5 complexes with 10 water molecules in minor and 15 water molecules ...

In addition, the cleavage pattern on opposite DNA strands reveals the orientation of the molecule at each site, in the minor groove asymmetric on the 3′ side and major groove on the 5′ side.

In 2012, Leung et al successfully imaged the major and minor grooves of a single DNA molecule with a 1 to 5mM NiCl 2 concentration for DNA adsorption onto a mica surface. Using the same DNA ...

Remarkably, without employing acceleration forces or bias, we captured a complete one-base-pair stepping cycle of the protein tracking along major groove of DNA with a homogeneous poly-adenosine ...

The contact occurs from both side of the DNA helix. Lysine 548 on the major groove and Lysine 607 on the minor groove. Other amino acids in vicinity to the lysine 548 (Asparagine 552: green, and ...

DNA has two kinds of grooves that play important roles in its functioning. Major and minor grooves help in formation of different proteins. These grooves bind proteins like transcription factors ...

Both ZFN and TALENs are modular proteins that interact with the major groove of the double helix structure of DNA in order to recognize specific base pairs. Each zinc finger module binds with a ...

Replacement of a conserved glycine–proline pair in the basic region by two lysines completely abolished DNA binding activity of TCP4 in electrophoretic mobility shift studies (Aggarwal et al., 2010).