Osteoclasts develop from the development of macrophages or monocytes, two types of immune cells. Suppressing osteoclast ...

A recent study that is yet to be published provided insights into the process of osteoclast differentiation and revealed potential therapeutic targets which can be pursued to develop treatments ...

A new study in mice shows how the small GTPase Cdc42 influences bone modeling and remodeling—it modulates both the formation and function of osteoclasts, and is involved in the downstream ...

These macrophages activate ATF6, which then enhances the transcription of TNFα by binding to its promoter. This process accelerates osteoclast activity, promoting bone resorption and speeding up ...

Patients with systemic sclerosis and calcinosis cutis may have a higher tendency for bone-resorbing cell activity, suggesting ...