This study presents an important finding on the role of GATA4 in aging and OA-associated cartilage pathology. The evidence supporting the conclusions is compelling, with rigorous in vitro and in vivo ...

Bone is a common site for metastasis of solid cancers, but histological and molecular features of bone metastases are not ...

Bone is a common site for metastasis of solid cancers, but histological and molecular features of bone metastases are not ...

In a new study published in Cell Genomics, researchers use RNA sequencing to characterize bone metastases from eight cancer types. The findings ...

A recent study reveals that dimethyl fumarate (DMF), a compound already approved for other inflammatory diseases, can prevent ...

In just 3 years, striking new advances have been made in understanding the molecular mechanisms that govern the crosstalk between osteoblasts/stromal cells and hemopoietic osteoclast precursor ...

We hypothesized that macrophages differentiate into osteoclasts in aneurysmal arteries and that protease byproducts contribute to aneurysm pathophysiology. We performed histological and ...

Osteoclasts arise from the differentiation of macrophages or monocytes, which are types of immune cells. Suppressing osteoclast differentiation can, therefore, serve as a therapeutic strategy to ...

Macrophages undergo plasma membrane fusion and cell multinucleation to form multinucleated giant cells (MGCs) such as osteoclasts in bone, Langhans giant cells (LGCs) as part of granulomas or ...