Patients with systemic sclerosis and calcinosis cutis may have a higher tendency for bone-resorbing cell activity, suggesting ...

These macrophages activate ATF6, which then enhances the transcription of TNFα by binding to its promoter. This process accelerates osteoclast activity, promoting bone resorption and speeding up ...

Bone marrow cells were flushed out and cultured in α-MEM complete medium supplemented with 10% fetal bovine serum (FBS), 1% penicillin–streptomycin, and 30 ng/mL macrophage colony-stimulating factor ...

The accumulation of inflammatory mediators in the joint cavity—including IL-1β, IL-18, and HMGB1—promote FLS pyroptosis, macrophage pyroptosis, chondrocyte pyroptosis and osteoclast formation.

nyumc.org Objective Netrin-1 is a chemorepulsant and matrix protein expressed during and required for osteoclast differentiation, which also plays a role in inflammation by preventing macrophage ...

New methods for deriving macrophages from induced pluripotent stem cells are easier to scale and provide more clinically relevant data.

Get Instant Summarized Text (Gist) Macrophages, part of the innate immune system, can exhibit a form of immune memory by adjusting their molecular signaling after an infection. This adaptation can ...

It’s estimated more than 10 million Americans over the age of 50 live with this "silent disease." Here's what osteoporosis ...

This study provides proof-of-principle data for the use of trained immunity to modulate macrophage interactions with tumours. The study makes a valuable contribution to the field of trained immunity.