Osteoclasts derive from a myeloid progenitor that gives rise to both the monocyte-macrophage lineage and the osteoclast lineage. A mononuclear pre-osteoclast exists that expresses both TRAP and CTR.

Osteoblast-mediated bone formation, osteoclast-mediated bone resorption and macrophage-regulated inflammatory response play a central role in the process of bone remodeling, which together maintain ...

The enzyme aconitate decarboxylase 1 (Acod1) is known to link the cellular function of monocyte-derived macrophages to their metabolic status. As osteoclasts derive from the monocyte lineage, we ...

Then, the body weight, femur indices, and serum biomarkers were examined and analyzed. In vitro, RAW264.7 murine macrophages were used as model of osteoclast formation. The effects of BTE and TRs on ...

RAW 264.7 Mouse monocyte/macrophages (TIB-71, ATCC, Manassas, Virginia, USA) 1×10 5 /well were cultured in 24-well plates and stimulated with 100 ng/ml purified glutathione-S-transferase (GST)-RANKL ...

We have observed that it inhibits both interleukin (IL)-1β and tumor necrosis factor (TNF) in vitro, and that it has anti-inflammatory properties and ability to decrease synovial CD68+ macrophages ...

Understanding why newborns, but not adults, can regenerate the heart could lead to treatments that "reprogram" adult ...

An increase in high-fat, high-fructose foods in people's diets has contributed to a dramatic increase in type 2 diabetes.

kuleuven.be Intestinal resident macrophages are at the front line of host defence at the mucosal barrier within the gastrointestinal tract and have long been known to play a crucial role in the ...

If Oregon’s recent cold snap has you shivering, and the ice and snow in the forecast seem unusual, take solace. The state climatologist feels it too — even when he’s looking at data that ...