Bone is a common site for metastasis of solid cancers, but histological and molecular features of bone metastases are not ...

In a new study published in Cell Genomics, researchers use RNA sequencing to characterize bone metastases from eight cancer types. The findings ...

Researchers conducted RNA sequencing and found the metastases fell into three distinct ecosystem archetypes characterized by enrichment of different immune cells: 1) macrophages and osteoclasts, 2) ...

Macrophages and other immune cells are the natural frontline immune warriors of our body, defending the body against invading ...

Background Current treatments with tyrosine kinase inhibitors and immune checkpoint inhibitors have limited efficacy for ...

This study presents an important finding on the role of GATA4 in aging and OA-associated cartilage pathology. The evidence supporting the conclusions is compelling, with rigorous in vitro and in vivo ...

Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, causing pain, fractures, and decreased quality of life. These conditions often ...

Feb. 27, 2025 — Red blood cells carry oxygen from the lungs to every other organ, and blood-forming stem cells must make about 200 billion new red blood cells each day to keep the oxygen flowing.