Bone-dissolving cells called osteoclasts are derived from a type of immune cells called macrophages. They are necessary for the maintenance and renewal of bones. But the intracellular mechanisms ...

Researchers from Tokyo Medical and Dental University (TMDU) found that light-mediated activation of RANK in macrophages induces them to differentiate into mature osteoclasts. This optogenetics ...

Osteoclasts are formed through differentiation from a certain type of immune cell called macrophage, after which they acquire their new role in the maintenance of bones and joints: breaking down ...

Now, a team of researchers in China and Australia has shown that SARS-CoV-2 infection can affect bone marrow macrophage (BMM)-to-osteoclast differentiation, which may impact the skeletal system.

Osteoclasts arise from the differentiation of macrophages or monocytes, which are types of immune cells. Suppressing osteoclast differentiation can, therefore, serve as a therapeutic strategy to ...

Osteoblasts and osteoclasts arise from distinct cell lineages: osteoblasts derive from mesenchymal stem cells (reviewed by Aubin ) and osteoclasts derive from hematopoietic monocyte-macrophage ...

Human exposure to toxic particles drives various diseases. Examples include gout, an acute arthritis driven by monosodium urate crystals, or MSUc; CPPD disease, another inflammatory joint disease ...