The Longevity India Conference 2025 - Rise for Healthy Aging, hosted at the Indian Institute of Science (IISc), concluded its final day with impactful discussions on longevity science. The discussions ...

Successful research in targeted protein degradation depends not only on measurements at high sensitivity, speed and precision ...

Lorsque ces cellules immunitaires avalent des bactéries, surtout mortes, elles recyclent une partie de leurs composés pour ...

Elevation Oncology, Inc. a publié ses résultats pour le quatrième trimestre et l'ensemble de l'exercice clos le 31 décembre ...

The biotech is focusing on precision, small-molecule medicines that work via a process known as cellular clearance by activating the lysosome, sometimes referred to as the cell’s recycling and ...

U.S., and colleagues have designed and constructed a lysosome-targeted photoinduced pyroptosis and ferroptosis theranostic nanoplatform M@P by self-assembly of photosensitizer MTCN-3 and ...

In a recent Perspective in Nature Immunology 1, Blander and Medzhitov explored the function of Toll-like receptor (TLR) signaling in controlling the maturation of phagosomes in macrophages and ...

Neurodegenerative diseases, including Alzheimer’s and Parkinson’s, are progressive conditions marked by neuronal loss, neuroinflammation, and protein ...

Mechanistically, Mtb Mce3C can bind host cathepsin B (CTSB), a lysosome-derived non-caspase protease that determines cell modalities. This binding inhibits CTSB's protease activity towards BH3 ...

So actually, enzyme replacement therapy is only useful if there's a way for the enzyme to get into the cell. So, beyond the lysosome, we can't do that.” Then there’s the promise of cell and gene ...

Les mucopolysaccharidoses (MPS) sont un groupe de sept maladies génétiques rares liées à la mutation d’un gène codant pour une enzyme impliquée dans la dégradation des déchets cellulaires.

The title should instead appear as “Hapalindole Q suppresses autophagosome−lysosome fusion by promoting YAP1 degradation via chaperone-mediated autophagy.” The legends for Figs. 1, 5, and 6 appeared ...