Lidocaine overdose can affect a person’s nervous and bodily functions in what is known as local anesthetic systemic toxicity (LAST). Symptoms are often related to the central nervous system (CNS ...

Accidental intravascular injection of large doses of local anesthetic is the most important trigger of LAST1 A slow injection technique (< 1 mL/s) with frequent aspirations and ultrasonography ...

The American Society of Regional Anesthesia and Pain Medicine has published a practice advisory on local anesthetic systemic toxicity (LAST) called “Guidelines for the Management of Severe Local ...

Toxicity symptoms in awake adults develop at lidocaine levels of 4.5–7.5 μg/mL. Increasing levels of local anesthetic correlate with a progression of symptoms, including circumoral paresthesia, ...

A new study published in the Feb. 2012 issue of Anesthesiology found that the type of lipid emulsion used to reverse toxicity of local anesthetics may change the effectiveness of the reversal, ...

Our results suggest that ultrasound guidance, HBV infection and the female sex are risk factors of LAST in LPBs and SNBs. For patients infected with HBV or female patients undergoing LPBs and SNBs ...

As the Teligent-written, FDA-posted recall notice states, this can lead to a dosage that’s too strong for the patient and that can lead to “local anesthetic systemic toxicity.” ...

Increased use of regional anesthesia can be ... being treated with long-acting local anesthetics prior to surgery may be at risk for local anesthetic toxicity. "We are working on a follow along ...