Ligand Pharmaceuticals Incorporated ... a dual endothelin and angiotensin II receptor antagonist for immunoglobulin A nephropathy; Ohtuvayre for respiratory disease; PNEUMOSIL, a pneumococcal ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Mapping an antibody’s epitope, where it binds a target, can now be done in three dimensions, which optimizes the selection of application-specific antibodies.

In this way, the small-molecule-binding proteins can be treated like ... spectrum of ligands (molecules that bind to protein receptors to send signals between cells), including cholic acid ...

Abstract: Predicting protein-ligand binding affinities is a critical problem in drug discovery and design. A majority of existing methods fail to accurately characterize and exploit the geometrically ...

The best 4K Blu-ray players deliver the ultimate picture quality for watching movies and TV series at home. Although streaming services are popular, Blu-rays deliver video at a higher bitrate ...

Proteins change their conformations as part of their biological functions, for example, when binding another molecule (ligand). Two pathways are conceivable: Either the ligand binds preferentially to ...

Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, 2318 Yuhangtang Road, Hangzhou 311121, PR China Department of Chemistry, and the ...

G Protein-Coupled Receptors (GPCRs) in advancing GPCR-targeted therapies, including the use of agonists, antagonists, biased ...

Failure to start resolution mechanisms might be due to limited availability of ligand-receptor interactions, a shortfall which might be corrected by exogenous delivery of FPR2 agonists. There are at ...