As concerns about waning antibiotic effectiveness grow, researchers are using unique tools to search for new ways to keep ...

The reported cryo-EM imaging of a pentameric ligand-gated ion channel in liposomes as opposed to nanodiscs has both broad implications and contributes valuable methodological advances to the ...

Ligand Pharmaceuticals’ topical skin infection gel Zelsuvmi is changing hands again—sort of. After Ligand last year created Pelthos Therapeutics to support the launch of Zelsuvmi, Pelthos is ...

Keeping in mind that CD40 Ligand-CD40 interaction pathway is involved in T-cell activation and GVHD pathophysiology, we designed this very first, phase I-Ib trial to assess whether blocking this ...

Capital will fund Castle Creek’s D-Fi Phase 3 clinical trial for patients with dystrophic epidermolysis bullosa through topline data results Ligand invested $50 million and a syndicate of co-investors ...

Judo Bio debuted Monday after about 3 years in stealth. The company has designed a drug candidate that combines a ligand with small interfering RNA (siRNA) that should silence messenger RNA (mRNA ...

Radiolabeling and spectroscopic labeling are the main types of label detection assays. Radiolabeling techniques include techniques such as radiometric ligand binding assays, which can include both ...

1 Free Energy Perturbation (FEP) calculations, a highly effective computational method, can accurately predict ligand binding affinities to GPCR targets. The binding affinity predictions (ΔG ...

Computational docking of the H1047R-selective ligand cpd22 suggests that utilizing the specific ... which represents the K D values obtained by fitting the binding curve with Biacore Insight ...

they obtain what they describe as "the first experimental evidence showing the correlation between molecular fluctuation and the gating state (ligand binding)." Once activated, the TRPV1 channel ...