Greater numbers of circulating stem cells increase the efficacy of in vivo gene therapy techniques, potentially reducing the price tag of lifesaving treatments.

Get Instant Summarized Text (Gist) Generative AI has been used to design synthetic DNA regulatory sequences that precisely control gene expression in healthy mammalian cells. These AI-generated ...

"LICONN brings us a step closer to assembling the puzzle pieces of the mammalian brain and better understanding its functioning both in health and disease," Danzl concludes.

Transduction involves using a non-replicating virus, like a modified lentivirus, to bring genetic material into the cell; transfection involves introducing genetic material using a non-viral method.

Lentiviral transduction is a popular and powerful gene delivery method for downstream applications such as cell line generation, therapeutic model generation and CAR-T research. However, current ...

We describe two patients in whom malignant monoclonal T-cell lymphoproliferation developed after administration of chimeric antigen receptor (CAR) T-cell therapy with ciltacabtagene autoleucel ...

Overall results of the lentiviral gene therapy show promise in overcoming a limitation of AAV-mediated approaches with the ability to bypass anti-AAV antibodies.

Autologous HSCs were transduced with CD68-ET3-LV — a lentiviral vector including a new F8 transgene (ET3) with a myeloid-directed CD68 promoter — either without transduction enhancer (group 1 ...

Lentiviral transduction of producer cells, followed by expansion of transduced cells, amplified the fraction of producer cells with a single barcode-capsid variant pair. The barcoded eVLP capsid ...

Increased evolvability of the mammalian ear The new study seemingly contradicts recent work on birds, reptiles and certain mammals that have cast doubt on the extent to which adaptive processes ...

We’re extremely excited by the potential impact of the transduction sponge on the production of important cell therapies." Several limitations in current methods make lentiviral transductions ...