efficient transduction of mammalian cells and safety of the baculoviruses. As a first step toward scalable lentiviral production system, we have constructed four recombinant baculoviruses ...

At this point lentiviral vectors can be used to transduce the mammalian cell line of choice ... In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science ...

More specific, local administration of lentiviral vectors into the retina or brain resulted in a stable transduction of ... into both cycling and non-cycling mammalian cells, zygotes, stem cells ...

Lentiviral transduction is a popular delivery platform for applications such as CAR-T cell engineering or CRISPR-Cas9 gene editing, as it can transduce both dividing and non-dividing cells and ...

Transduction involves using a non-replicating virus, like a modified lentivirus, to bring genetic material into the cell; transfection involves introducing genetic material using a non-viral method.

To improve the efficacy of gene therapy when using anti-sickling beta globin gene transfer, they added cyclosporin (CsH) to increase transduction by inhibiting lentiviral restriction factors.

A new vector system known as lentiviral vectors can permanently integrate the gene into dividing and non-dividing cells. The capacity of lentiviral vectors to reliably integrate at various genomic ...

MxV-G is a novel fusogen for lentiviral packaging that achieves higher vector titers and enhanced transduction efficiency. The detargeted MxV-G mutant abolishes native receptor binding while ...

Autologous HSCs were transduced with CD68-ET3-LV — a lentiviral vector including a new F8 transgene (ET3) with a myeloid-directed CD68 promoter — either without transduction enhancer (group 1 ...

By measuring the activities of a reporter, AMSBIO Reporter Lentivirus can be used for performing gene regulation studies in living mammalian cells and for ... sensitive and quantitative monitoring of ...