The kinesin motor domain is composed of a single globular catalytic core and a short strand 'neck linker'. The catalytic core contains both the ATPase reaction centre and the microtubule binding ...

The antimitotic properties of parthenolide, a natural compound with known anticancer activity, have been largely ...

School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, P. R. China CAS Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of ...

Edited by Ken A. Dill, Stony Brook University, Stony Brook, NY, and approved September 26, 2019 (received for review August 6, 2019) ...

Kinesin motor proteins facilitate microtubule-based transport by converting chemical energy into mechanic forces, but this activity is autoinhibited until cargo is loaded. Regulatory mechanisms ...

We demonstrate highly efficient rectification of microtubule motility on gold nanofabricated structures ... well-understood PEG−silane chemistry on SiO 2 for the blocking of kinesin, whereas the gold ...

Abstract: The cytoskeletal motor protein kinesin-1 has been successfully used for many nanotechnological ... Longer run times cause problems like microtubule shrinkage, microtubules getting stuck and ...

investigate how microtubule organization within pancreatic islet beta cells supports optimal insulin secretion. Using a combination of live imaging and photo-kinetic assays in an in vitro culture ...

Here, we developed and applied a high-precision 3D-optical-tweezers force clamp to track in vitro the 3D motion of single kinesin-1 motor proteins along microtubules. To provide the motors with ...