This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and ...

Kinesin-1-powered microtubules have emerged as versatile components ... This approach offers a transformative solution for recording microtubule trajectories within nanotechnological devices by ...

Nesprin-1/2 directly bind actin, nesprin-3 is connected to intermediate filaments (IFs) by plectin and nesprin-4 binds microtubules (MTs) through kinesin-1 or other microtubule motor proteins. In the ...

HDAC6 is upregulated in corneal diseases and causes ENKD1 deacetylation at lysine 98. Deacetylation of ENKD1 blocks its ...

Despite this complexity, all axonal transport events are carried out by the same set of machinery: microtubules and microtubule motor proteins (dynein and kinesins). There is now a large body of ...

This has a direct impact on MT function in the formation of the cytoskeletal architecture and as track for axonal and organelle transport, and is resumed in the “Tau-microtubule hypothesis” (Alonso et ...