Vision changes are an inevitable part of aging, but why are some more susceptible to age-related eye diseases and why do some individuals experience more severe decline than others?

Researchers used mice with nine different genetic backgrounds to identify factors influencing eye aging, paving the way for eye-based diagnostics for neurodegenerative diseases.

Originally collected on the island of Castania and brought to JAX in 1971, CAST mice were bred at JAX to maintain a genetically pure line, creating a model as true to the mouse genome as possible.

In a first, aging-related gene expression changes in breast tissues are linked to alterations in chromatin accessibility.

Heart tissue in healthy mice (left). Heart tissue in MSD mice (middle). When MSD mice received a bone transplant from healthy mice, the unhealthy heart tissue became healthy. In two new papers ...

Aging is a privilege, but it also brings risks-including an increased likelihood of developing age-related diseases including cancer.

From mice to humans: A shared cancer link To see ... Ph.D., an associate research scientist at JAX and co-first author of the study. "It suggests that aging-related shifts in healthy tissue ...

Many of our transgenic lines come from the Jackson Laboratories, an NIH-supported repository for genetically engineered mice. All of our published lines are available either through Jax or the related ...