New research challenges the view that proteins are the only key to evolution, highlighting the importance of lipids.

The complexes sit in the inner mitochondrial membrane, where they interact ... of mutations on the lipid-facing surfaces of Complex I proteins — parts not involved in protein-protein interactions.

Africa, Latin America, and certain regions of Asia face a heavy burden: diseases transmitted by insects, such as mosquitoes or tsetse flies. These often neglected diseases do not just devastate ...

Discover the three critical minerals that become increasingly important for women after menopause, affecting everything from ...

(3) This alteration in mitochondrial function aberrantly activates PI3K, (4) which phosphorylates PIP2 on the cell membrane ... AKT, Protein Kinase B. In summary, MRPs significantly influence immune ...

with the inner membrane cristae being beyond the spatial resolution limits of conventional confocal microscopy. TEM imaging by Sesaki et al. found a lack of Cu in the mitochondrial matrix due to the ...

Human complex II deficiency resulting from mutations in the structural subunit genes can lead to metabolic disease or cancer. Here, we have determined the structure of this complex which explains how ...

Mitochondria are membrane-bound cell organelles that undertake the majority ... and −503 improves muscle protein synthesis mitochondrial density and enhances ATP production (Long et al., 2023). Within ...

The mitochondrion plays critical roles in cellular function, making it a prime organelle to target for fundamental studies, ...