How do mitochondrial organelles remove damaged parts of inner membrane for recycling in the cytoplasm? The discovery of an exit route that flips inner membrane outside the organelle provides some ...

The presequence translocase of the inner mitochondrial membrane (TIM23 complex) is essential for importing cleavable preproteins into mitochondria. The preproteins contain amino-terminal targeting ...

Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell ...

Individual mitochondria are capsule shaped, with an outer membrane and an undulating inner membrane, which resembles protruding fingers. These membranous pleats are called cristae, and serve to ...

Panel A shows how mitochondria join through the process of fusion, which is mediated by the coordinated activities of mitofusins in the outer mitochondrial membrane and OPA1 in the inner ...

During this process, cellular redox energy from the breakdown of food is converted to a proton gradient across the inner mitochondrial membrane (called the proton motive force), which is ...

The findings are published in Nature in an article titled, “Lysosomes drive the piecemeal removal of mitochondrial inner membrane.” “Mitochondrial membranes define distinct structural and f ...

A 3D reconstruction showing the inner mitochondrial membrane (red) herniating into a closely associated lysosome (green). The outer mitochondrial membrane is shown in blue and the nucleus is shown ...

In addition to the supercomplexes, the researchers were also able to examine the membrane architecture of the mitochondria more closely. "It's somewhat reminiscent of lung tissue: the inner ...

“The mitochondrial permeability transition pore (MPTP) is a megachannel in the inner mitochondrial membrane that opens in response to high matrix Ca2+ and oxidative stress,” the authors note ...

The researchers named the novel process VDIM formation, which stands for vesicles derived from the inner mitochondrial membrane. By removing damaged cristae through VDIMs, cells can prevent harm ...