A comparison of histological sections of pancreata from 15- and 30-week-old non-diabetic NOD female mice treated with Ad5mIL-4 or DL70-3 control at 2 weeks of age only or at 5 and 7 weeks of age ...

Wenzhou Medical University researchers have reimagined the spleen as a viable site for islet transplantation, enabling long-term diabetes control without the burden of full immunosuppression.

The experiments were performed in accordance with regulations specified by the National Institutes of Health "Principles of Laboratory Animal Care, 1985 Revised Version" and University of Michigan ...

In this study, we evaluated whether TLR4 activation by endogenous or gut bacteria-derived TLR4 agonists contributes to the overproduction of corticosterone in diabetic mice. As corticosterone is ...

Objective: This study aimed to investigate the effects of PAItrap3, a novel PAI-1 inhibitor, on lipid metabolism, and autophagy pathways in diabetic mice.Methods: db/db diabetic mice were administered ...

By using a sensitive search strategy and including all study designs, this review comprehensively analyses the evidence for patient activation in type 2 diabetes (T2D). We derive levels of evidence, ...

Islets were obtained from healthy and type 2 diabetic human donors, and mice on chow or high fat diet. All major islet hormones were detected in lysed islets as well as numerous peptides from ...

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hajipur 844102, India ...