News Medical on MSN11d
Most engineered human cells created for studying diseaseThis is the first time that it's been possible to 'shuffle' a mammalian genome, especially at this scale. The team then ...
The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the ...
Complex engineering of human cell lines reveals genome's unexpected resilience to structural changes
This is the first time that it's been possible to 'shuffle' a mammalian genome, especially at this scale. The team then studied the impacts of the structural variation on the human cell lines. Using ...
The human genome can have some quirky features, like copy number variation. When this happens, an individual carries, or loses bits of DNA, which ... | Genetics And Genomics ...
They then deployed genome sequencing to analyse the genetic effects of these structural variations on cell survival. It ...
Structural variants in the human genome include cytogenetically detectable and submicroscopic deletions, duplications, large-scale copy-number variants, inversions and translocations. The ability ...
This is the first time that it’s been possible to ‘shuffle’ a mammalian genome, especially at this scale. The team then ...
Materials & methods: A computational analysis of genetic and functional differences of the 57 CYP450 genes was performed using the Human Genome Diversity Project and HapMap data; comprising ...
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