Toxicity related to the systematic delivery of IL-12, a well-known and widely researched anti-tumor cytokine, has limited its ...

but only as a monotherapy in patients with tumours that express homologous recombination repair (HRR) gene mutation – including BRCA1/2 and ATM. If Pfizer gets FDA approval on the strength of ...

For many of us, GameCube games on Nintendo Switch Online kind of felt like the holy grail. Granted, it very much depends on your age and which systems you happened to grow up with, but with the ...

Mechanisms were explored via LC‒MS/MS, coimmunoprecipitation, laser microirradiation, immunofluorescence, the homologous recombination (HR) or non-homologous end joining (NHEJ) reporter system, in ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Corneal diseases can cause severe visual ...

(17) This unexpected finding led us to propose that a domain insertion at the inside can be deployed to capture a cognate protein or ligand inside the capsid during AAV production, effectively ...

The Drosophila Gateway™ Vector collection is a set of ... At its core is Invitrogen's Gateway™ recombination cassette, which allows you to recombine an Open Reading Frame (ORF) of interest into any of ...

The synthesized promoter is cloned into an expression vector, and the expression is validated through ... However, synthetic DBDs can still display off-target binding to homologous sequences. Online ...