This valuable study focuses on defining how the HSP70 chaperone system utilizes J-domain proteins to regulate the heat shock response-associated transcription factor HSF1. Using a combination of ...

Researchers developed a biomimetic nanovesicle that crosses the blood-brain barrier, degrades DNA repair proteins, and ...

homologous recombination, mismatch repair and nucleotide excision repair. Newly manufactured DNA repair proteins or assays shield cells from genomic instability and carcinogenesis. Along these ...

Centrioles are required for fully proficient double‐strand break repair by HR. Subdistal appendage proteins promote DNA end resection ... correlates with poorer cancer prognosis. (A) Homologous ...

Homologous recombination repair (HR) is an error-free pathway to repair DNA double ... DDRM1 is an evolutionarily ancient protein, which is identified in mosses, the first land plants, indicating that ...

In addition to its roles in HR, Metnase also promotes DSB repair by classical non-homologous recombination, and chromosome decatenation mediated by TopoIIα. Although mutations in Metnase and EEPD1 are ...

A protein with many jobs Although the ... previous surprising finding that XPG plays a role in homologous recombination -- a DNA repair process frequently used by cells to fix dangerous double ...

Therefore, we previously developed the Repair Capacity (RECAP) test, a functional homologous recombination (HR ... such as loss of 53BP1 protein. Loss of 53BP1 was examined but not found in any ...