Figure 1: Mechanism of nucleotide excision repair and base excision repair. The protein factors that are required for TCR and general genome repair (GGR) of DNA damage fall into two broad groups.

This valuable study focuses on defining how the HSP70 chaperone system utilizes J-domain proteins to regulate the heat shock response-associated transcription factor HSF1. Using a combination of ...

Researchers developed a biomimetic nanovesicle that crosses the blood-brain barrier, degrades DNA repair proteins, and ...

V(D)J recombination allows the vertebrate immune system to generate a diverse array of antigen receptors. Because this process introduces double-strand DNA breaks millions of times each day, it is ...