The prevalence of obesity is increasing worldwide, affecting both children and adults. This obesity epidemic is mostly driven by an increase in energy intake (abundance of highly palatable ...

The authors use deep mutational scanning to assess the effect of ~6,600 protein-coding variants in MC4R, a G protein coupled receptor associated with obesity. They develop new, more precise approaches ...

Genome-wide association studies (GWAS) have been widely employed to identify genetic variants that are associated with risk for disease and physiologically relevant traits (Tam et al., 2019; Visscher ...