Genetic studies can offer powerful insights for the development of disease-modifying therapies for Alzheimer's disease.

Dosing complete in the first two cohorts of INLIGHT trial in obesity of WVE-007 (INHBE siRNA), designed to induce healthy weight loss by reducing fat without impacting muscle; clinical data on track ...

Double-jointed? It’s not just a fun party trick. Uber-flexible joints could be a sign of a rare genetic condition that makes you more susceptible to respiratory illnesses and also complicates ...

Objective Huntington disease (HD) is an autosomal dominant neurodegenerative disease involving motor disturbances, cognitive decline and psychiatric symptoms. Psychotic symptoms occur in a significant ...

Background The relatively focal and specific loss of striatal medium spiny neurons in Huntington’s disease (HD) makes the disorder a suitable candidate for cell replacement therapy (CRT), a process ...

At 24 months, additional benefits were observed, including dose-dependent trends on the Composite Unified Huntington’s Disease Rating Scale (cUHDRS) and other subscales, as well as a reduction in ...

BUFFALO, N.Y. — A decade ago, University at Buffalo researchers shed some light on an enduring neuroscience mystery: How exactly does a mutated huntingtin protein (HTT) cause Huntington’s disease?

If someone’s parent has Huntington’s, they have a 50% chance of inheriting the deadly disease. Conley says it’s like having Alzheimer’s, ALS and Parkinson’s all at once.

They found that two specific signaling proteins, GSK3ß and ERK1, were expressed more in the neurons of Huntington’s disease patients, so they prevented them from functioning in the neurons of ...

The number of people who have the gene that causes Huntington's disease in Northern Scotland has been accurately counted for the first time in 35 years in new research from the University of ...

Shares in PTC Therapeutics fell by double-digits Monday morning as investors parsed new clinical trial results for an important Huntington’s disease drug the biotechnology company has been developing.