News

Gene editing disrupts Huntington's mutation in mice
Broad Institute researchers have developed a way to edit the genetic sequences at the root of Huntington's disease and ...
A common sleep aid blocks neurodegeneration in mice
A common sleep aid restores healthier sleep patterns and protects mice from the brain damage seen in neurodegenerative ...
AHA/ASA Journals5d
Disruption of cTnT-Mediated Sarcomere–Mitochondrial Communication Results in Dilated Cardiomyopathy
BACKGROUND: Dilated cardiomyopathy (DCM) is substantially influenced by genetic factors. Sarcomere function is intricately associated with other organelles, particularly the reciprocal regulation ...
eLife4d
Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to lethality in mice
This fundamental work presents two clinically relevant BMP4 mutations that contribute to vertebrate development. The compelling evidence, both from wet lab and AI generated predictions, supports that ...