These ES cells are heterozygous for the knockout mutation. Although these cells will grow and divide in culture, they cannot form an embryo that will develop into a mouse on their own. Step 4 ...

with a homozygous floxed mouse (B). The offspring are heterozygous for the floxed target gene (C) and breed with the homozygous floxed mouse (B). The resulting experimental mouse is hemizygous for Cre ...

This was more evident in mature mice, with heterozygous mice showing an intermediate phenotype (Fig. 3e). The presence of these hemorrhagic structures may result from the normal process of ...

White fur is recessive - a. Grey fur is dominant - A. Two mice that are heterozygous for the fur colour gene mate. Determine the probability that the offspring will have grey fur. Because the ...