The biosynthesis of the great variety of natural plant products has not yet been elucidated for many medically interesting substances. In a new study, an international team of researchers was able to ...

This research combines metabolomic profiling with biosynthetic pathway analysis to identify potential precursors and enzymes involved in musk biosynthesis. Limited evidence regarding the function and ...

Scientists have re-created a pain pathway in the brain by growing four key clusters of human nerve cells in a dish. This laboratory model could be used to help explain certain pain syndromes ...

Variants in genes encoding common components of the growth hormone signaling pathway (e.g., GHR mutations in Laron syndrome) have been identified as contributors to monogenic short stature.

Key Laboratory of Smart Drug Delivery, Ministry of Education, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, School of Pharmacy, Fudan University, Shanghai ...

Key Laboratory of Chemical Biology (Ministry of Education), Shandong Basic Science Research Center (Pharmacy), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250012, China CAS ...

Researchers identify the crucial protein for controlling the biosynthesis of steroidal glycoalkaloids and saponins in plants of the genus Solanum and for the first time demonstrate the ecological ...

In preclinical models of peripheral arterial disease, further activation of EC glycolysis was ineffective or deleterious in promoting hypoxia-dependent angiogenesis, whereas pentose phosphate pathway ...

Tsukuba, Japan—Researchers have been studying the transcription factor SREBP, a critical regulator of lipid biosynthesis ... The RHBDL4-SREBP-1c pathway, uncovered in this study, represents ...

In this report, the authors devised synthetic genomic strategies to introduce essential amino-acid biosynthetic pathways into mammalian cells. While the functionalization of methionine, threonine, and ...