Scientists discovered a novel signaling pathway in liver cells, leading to a treatment for fibrosis. A healthy liver filters all the blood in your body, breaks down toxins and digests fats.

After discovering the signaling pathway, the scientists designed a ... proved the viability of the pathway but also prevented liver fibrosis - too much collagen in the liver - without causing ...

45 Hepatic fibrosis typically results from an inflammatory ... 1 and angiotensin II), and integrin–extracellular matrix signaling pathways. The fact that tissue fibrosis is remarkably plastic ...

In the liver, TGF-β signaling is involved in maintaining liver homeostasis and responding to injury by modulating inflammation and fibrosis. HIPPO Pathway: The HIPPO pathway is a kinase cascade ...

affects liver fibrosis through multiple mechanisms. However, research on COX-2 regulation of ferroptosis in chronic liver injury remains limited. This study aimed to investigate whether and how ...

The results of this study demonstrate that HO-1 helps reduce hepatic fibrosis associated with NAFLD by modulating the SIRT1/TGF-β/Smad3 signaling pathway. Insights into the interactions between ...

Metabolic dysfunction-associated steatohepatitis (MASH) significantly increases the risk of liver cirrhosis and hepatocellular carcinoma. While fibroblast growth factor 21 (FGF21) analogs have shown ...

The STING pathway also activates the NF-κB signaling cascade ... contributing to hepatic inflammation and fibrosis. Mitochondrial DNA (mtDNA) released from damaged hepatocytes can also activate ...

The aim of this study was to compare the fibrosis seen in liver biopsy samples to the signal intensity of the hepatobiliary phase measured on EOB-MRI in hepatitis C virus (HCV)-infected patients.

After discovering the signaling pathway, the scientists designed a ... proved the viability of the pathway but also prevented liver fibrosis—too much collagen in the liver—without causing ...