JUV-161 is a first-in-class muscle regenerating biologic that will address myopathies starting with Myotonic Dystrophy Type 1 JUV-161 was discovered using Juvena's proprietary JuvNET platform, an AI ...

Aramchol, an SCD1 inhibitor, significantly attenuates and prevents biliary fibrosis in mouse models of primary sclerosing cholangitis (PSC) Aramchol treatment leads ...

Elecsys PRO-C3, used with the ADAPT formula (age, diabetes status, PRO-C3, platelets), assesses liver ... fibrosis (≥F2), advanced fibrosis (≥F3), and cirrhosis (F4). This is crucial for determining ...

The results of this study demonstrate that HO-1 helps reduce hepatic fibrosis associated with NAFLD by modulating the SIRT1/TGF-β/Smad3 signaling pathway. Insights into the interactions between ...

affects liver fibrosis through multiple mechanisms. However, research on COX-2 regulation of ferroptosis in chronic liver injury remains limited. This study aimed to investigate whether and how ...

Metabolic dysfunction-associated steatohepatitis (MASH) significantly increases the risk of liver cirrhosis and hepatocellular carcinoma. While fibroblast growth factor 21 (FGF21) analogs have shown ...

plays a crucial role in promoting the progression of liver fibrosis. Abnormal expression of signaling pathways, such as the TGF-β/Smads pathway, contributes to HSCs activation. Recent studies have ...

In the liver, TGF-β signaling is involved in maintaining liver homeostasis and responding to injury by modulating inflammation and fibrosis. HIPPO Pathway: The HIPPO pathway is a kinase cascade ...

Scientists discovered a novel signaling pathway in liver cells, leading to a treatment for fibrosis. A healthy liver filters all the blood in your body, breaks down toxins and digests fats.

After discovering the signaling pathway, the scientists designed a ... proved the viability of the pathway but also prevented liver fibrosis—too much collagen in the liver—without causing ...

We put the pathway together, showing each step in this intracellular signaling module. That was the science of the research. The clinical message is this ASO, which can actually block liver fibrosis,” ...