Studies have begun to show the lineage relationships between and molecular programs controlling hematopoietic cell emergence in the conceptus and the legacy of the cells emerging from distinct ...

Diverse results from many experimental systems indicate that the proliferative and self-renewal capacity of a given hematopoietic cell, as well as the diversity of lineages to which it can ...

First-in-class approach enables the generation of transgene-free hematopoietic stem cells through mechanosensitive PIEZO1 activation Stratus has an exclusive license to the intellectual property for ...

The hematopoietic stem cells can form red blood ... stem cells as tissues contain large numbers of several types of cells. Lineage analysis is one method used to tackle this problem.

Hematopoietic progenitor cells (HPCs) are an intermediate cell type in blood cell ... CMPs and CLPs continue to differentiate along cell lines into lineage-restricted progenitor cells that become ...

Then they mapped single-cell lineage output to gene expression against a cDNA library to generate a molecular bridge database. Lu and her team used the database to quantify HSC lineage outputs across ...

Buildup of lipid peroxides can affect critical cells called hematopoietic stem cells (HSCs ... impacted HSCs and immune cells with B cell lineage (types of white blood cells) but had few effects ...

Stem cells can produce any other cell type, it is just a matter of telling them in the right way. From a biological perspective, this means activating the proper genetic programme by pressing the ...

Researchers use generative AI to design synthetic enhancers that can effectively control gene expression in healthy mammalian cells.

Researchers identified 55 distinct hematopoietic cell states across the dataset ... These patterns reflected both early developmental blocks and lineage-biased differentiation toward myeloid ...