These events are associated with innate training and can have long-term impacts on hematopoietic stem and progenitor cell (HSPC) development but can also compromise their function. While many ...

Human pluripotent stem cells (hPSCs ... expression of lineage-specific genes, abnormally increased mitochondrial activity, and altered chromatin accessibility to hematopoietic transcription ...

Since the lineage transition is progressive in time, we performed single-cell transcriptomic analysis on index-sorted mammary cells at different stages of lineage conversion, generating a temporal map ...

1Children’s Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas. 10Howard Hughes Medical Institute, UT Southwestern Medical Center, ...

A senior undergraduate student from the East China University of Science and Technology becomes the 700th donor of hematopoietic stem cells in Shanghai on March 25, 2025. [Photo provided to ...

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Then they mapped single-cell lineage output to gene expression against a cDNA library to generate a molecular bridge database. Lu and her team used the database to quantify HSC lineage outputs across ...

View Full Profile. Learn about our Editorial Policies. Hematopoietic stem cells (HSCs) are multipotent progenitor cells found in the blood and bone marrow. They have the ability to self-renew, and ...

In the hematopoietic microenvironment in human bone marrow ... active bone generation and the location of SSCs was vividly shown above. Adipocyte lineage cells represent a branch of BMSCs after the ...

To test the effect of inflammatory cytokines on hematopoietic cell lineage, either DMSO vehicle or IL-1β (25 ng/ml), TNF-α (1 μg/ml), AS101 (2 μg/ml, IL-1β inhibitor) and R7050 (2 μg/ml, TNF-α ...