Studies have begun to show the lineage relationships between and molecular programs controlling hematopoietic cell emergence in the conceptus and the legacy of the cells emerging from distinct ...

Hematopoiesis is the process that generates blood cells of all lineages. Calculations based on the blood volume and the level and half-life of each type of blood cell in the circulation indicate ...

The technology, which is called CRISPR Array Repair Lineage tracing (CARLIN), was ... biases in the activity of fetal liver hematopoietic stem cell (HSC) clones and to uncover a previously ...

Using the mutation patterns in the hematopoietic stem and progenitor cells (HSPCs) the team was able to trace the developmental lineage tree of the cells. Researchers from the Princess Máxima ...

Scientists at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, have found that gene editing using ...

They report their work in Science in a paper titled “Isolation of Single Human Hematopoietic Stem ... of HSCs are CD34 +, most CD34 + cells are actually lineage-restricted progenitors.

Then they mapped single-cell lineage output to gene expression against a cDNA library to generate a molecular bridge database. Lu and her team used the database to quantify HSC lineage outputs across ...

Hematopoietic progenitor cells (HPCs) are an intermediate cell type in blood cell ... CMPs and CLPs continue to differentiate along cell lines into lineage-restricted progenitor cells that become ...

Ahn suspects, however, that ZTTK patients’ HSC are causing an imbalance in cell lineage. “We think there is a defect in the hematopoietic stage in that it’s creating more myeloid cells and red blood ...

Disease progression, which leads to loss of neurologic function and death, can be halted only with allogeneic hematopoietic stem-cell transplantation. We enrolled boys with cerebral ...