NNRTIs bind to a hydrophobic pocket near the catalytic site of HIV-1 RT and inactivate enzymatic activity. NNRTI-resistance mutations & their mechanism of drug resistance The most prevalent NNRTI ...

A Norwegian man has been free of the virus for nearly two and a half years following treatment and is likely cured of HIV.

Resistant individuals had in their cells two copies of a mutation that disrupted the entryway through which HIV viruses entered white blood cells. People who inherited just one copy of the change ...

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a ...

However, the optimal means of interpreting these sequences is not known. HIV-SEQ identifies mutations and helps in their interpretation, but does not have the logical or heuristic power to provide ...

Two more people have potentially been cured of HIV after undergoing stem cell transplants. Like others, the patients received stem cells from donors with a mutation that makes them resistant to HIV.

Dolutegravir plus lamivudine shows comparable efficacy and safety with standard-of-care three-drug regimen in patients with ...

In a new study, people living with HIV who got standard meds to keep the ... a gene found in neurons undergoes mutations that can produce thousands of new gene variants. The Alzheimer's-linked ...

For the reports involving oral PrEP, genetic testing of the HIV acquired in all but one breakthrough case detected mutations associated with resistance to emtricitabine, tenofovir, or both. For ...

An effective HIV-1 vaccine must therefore elicit antibodies that can neutralize many variants of the virus. While broadly neutralizing antibodies (bnAbs) have been isolated from HIV-1 infected ...