Skin, large intestine and liver were evaluated in both allogeneic and syngeneic transplanted mice at day +7 (beginning of GVHD) and +21 (established phase of GVHD) after BMT.

IL-2 mRNA in spleen and skin of GVHD affected mice. A quantitative IL-2 RT-PCR was developed with an IL-2 competitor fragment that was shorter than the wild-type sequence.

JAX, with over 11,000 strains, enables access to cutting-edge, humanized-PBMC-NSG™- mice—one of the most widely used models to study human-to-mouse-xenogeneic GvHD, as well as immune function ...

GVHD-related skin issues can range from mild to severe, so work closely with your GVHD care team to manage and treat them. Lifestyle changes, medications, and a type of light therapy can all help ...

Up to 70 percent of people with acute GVHD will experience skin problems, including dry, itchy, or sensitive skin, along with rashes or redness of the feet and palms, says Dr. Borogovac. [1] ...

Subsequent bone marrow transplant experiments in mice lacking MHC-II expression resulted in less severe GVHD than those mice with MHC-II expression. Explaining the rationale behind these first ...

The skin (dermatitis), liver (hepatitis), and GI tract (enteritis) are the main target organs of GVHD. Lung involvement can also occur. GVHD can manifest as an acute or chronic disease process ...

Acute GVHD can affect the skin, liver, and gut. It can cause various symptoms, such as skin rashes, diarrhea (sometimes with stomach pain and vomiting), or an increase in liver enzymes.

Acute GvHD happens shortly after a transplant and often affects the skin, intestines or liver. Chronic GvHD can happen any time ... the severity of chronic GvHD and increased survival in mice.

It was as if the enzyme produced by the skin graft had immunized the mice against a cocaine overdose. We then assessed whether hBChE-producing cells can protect against development of cocaine-seeking.

Graft-versus-host disease (GVHD) is a common side effect in people who receive cells from a donor (allogeneic transplant). It occurs when the transplanted cells recognize the recipient’s tissues as ...