To explore the role of Langerhans cells in GVHD, the principal dendritic cells of the skin, we studied the fate of these cells in mice transplanted with allogeneic bone marrow. In contrast to ...

3 Chronic GvHD also tends to start with a burning rash on the same parts of the body, although it can be more severe and ...

During a live event, Catherine J. Lee, MD, MS, discussed the efficacy and safety results of various trials of approved agents ...

Healthcare professionals determine how to administer steroid therapy based on the severity of GVHD. If symptoms are localized and mild, such as a rash on the skin, topical products might be the ...

the potential for GvHD is greatly reduced. The dual effect has been demonstrated in mouse models of allogeneic HSCT, and mocravimod has been found to be safe and well-tolerated in human safety ...

GvHD causes life-threatening immune system reactions in the skin, gastrointestinal (GI ... Many differences exist between human and mouse immune systems and their MSCs. Instead, he says, more ...

Grafts in untreated diabetic mice are rejected ... in the absence of GVHD. Fourth, we can generate central transplantation tolerance that supports allogeneic skin transplantation and will surely ...

Graft versus host disease (GvHD) is a complication from stem cell transplants where the patient recognises the cells as ...

The regulator has cleared Ryoncil (remestemcel-L) to treat steroid-refractory acute GVHD in paediatric patients aged two months and older. It is derived from MSCs harvested from the bone marrow of ...

The FDA has approved Incyte's axatilimab as a treatment for chronic graft-versus-host disease (GvHD), making it a companion to the company's Jakafi for the disorder. The US regulator has cleared ...