Our brain requires a constant supply of energy. A disrupted energy supply, as, for instance, caused by a stroke, can have ...

A new study shows that when energy is depleted—such as during a stroke—neurons begin releasing glutamate in abnormal, self-amplifying bursts that can damage nerve cells.

The molecular mechanism behind why heart attacks can vary in severity depending on the time of day has been uncovered by ...

The gut microbiome supports health through balanced metabolic exchanges, but in type 2 diabetes rising blood glucose shifts interactions from cooperation to competition, altering cross-feeding ...

This useful study reports a method to detect and analyze a novel post-translational modification, lysine acetoacetylation (Kacac), finding it regulates protein metabolism pathways. The study unveils ...

Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes ...

University of Iowa, Iowa City, IA.