New 100-week data from the ongoing Phase 1/2 study of zigakibart, an investigational anti-APRIL monoclonal antibody, ...

New 100-week data from the ongoing Phase I/II study of zigakibart, an investigational anti-APRIL monoclonal antibody, ...

IgA nephropathy (IgAN) is characterized by the deposition of IgA1-containing immune complexes in the glomerular mesangium. The pathogenesis follows a 4-hit cascade: ...

Panelists discuss how patient-reported outcomes including symptom burden, treatment-related adverse effects, preserved ...

THE constitutional character of atopic dermatitis is generally recognized. 1 The frequent association of this dermatitis with hay fever, asthma and urticaria and the demonstration of specific ...

More information: Yoshihito Nihei et al, Identification of IgA autoantibodies targeting mesangial cells redefines the pathogenesis of IgA nephropathy, Science Advances (2023). DOI: 10.1126/sciadv ...

Glomerulonephritis refers to acute and chronic kidney diseases caused by injury to the glomerulus, a part of the kidney responsible for filtering blood. If the kidney is injured, it is unable to ...

As Dr. Lerma explains, "Targeting APRIL and the 4 hit process represents a potential therapeutic strategy to disrupt IgA nephropathy's pathogenesis. This is the process in which pathogenic Gd-IgA1 ...

“Dual APRIL/BAFF inhibition is a potent inhibitor of Galactose Deficient IgA1 (Gd-IgA1) production which is closely linked to the pathogenesis and progression of IgA nephropathy. Monthly ...

As a result, autoimmune symptoms such as autoantibody concentrations, immune cell infiltration into body tissues, and renal glomerulonephritis ... a mechanism of SLE pathogenesis involving ...

New 100-week data from the ongoing Phase 1/2 study of zigakibart, an investigational anti-APRIL monoclonal antibody, reinforce its potential as a disease-modifying treatment for IgA nephropathy (IgAN) ...