Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase, the mitochondrial electron ...

The global IgA nephropathy market is poised for substantial growth, with sales projected to increase from USD 46,821.7 million in 2025 to a remarkable USD 99,655.4 million by 2035. According to the ...

Panelists discuss how disease-modifying therapies for immunoglobulin A (IgA) nephropathy, though initially more expensive than symptomatic treatments, offer substantial long-term cost benefits by ...

Panelists discuss how early diagnosis of immunoglobulin A (IgA) nephropathy enables timely interventions that can ...

Japanese drugmaker Otsuka Pharmaceutical (TYO: 4578) today announced the US Food and Drug Administration (FDA) has accepted ...

First non-immunosuppressive dual-action therapy recommended by NICE for eligible patients with IgA nephropathy, a leading cause of kidney fai ...

5 Here, we demonstrate that HFD exacerbates lupus pathogenesis and the development of autoimmunity in MRL/lpr mice, characterised by significantly increased dermatitis, splenomegaly, ...

We studied multiplex IgAN kindreds from Italy (24 kindreds) and the United States (6 kindreds). All were ascertained through biopsy-documented IgAN cases and had at least one more affected member.

Coronavirus disease 2019 (COVID‐19) is an infectious disease caused by severe acute respiratory syndrome coronavirus‐2, which has posed a significant threat to global health. Although the infection is ...

cDepartment of Endocrinology and Metabolic Diseases, Larissa University Hospital, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece dDepartment of Endocrinology ...

As Dr. Lerma explains, "Targeting APRIL and the 4 hit process represents a potential therapeutic strategy to disrupt IgA nephropathy's pathogenesis. This is the process in which pathogenic Gd-IgA1 ...

Nephropathy is the deterioration of kidney function. The final stage of nephropathy is called kidney failure, end-stage renal disease, or ESRD. According to the CDC, diabetes is the most common cause ...