As researchers work to improve treatment of Alzheimer's disease, new research by UCLA Health identified a candidate drug that ...

They found that mice lacking the cystathionine γ-lyase enzyme experienced the most significant weight loss, nearly 31%, on ...

The scientists at the University of California, San Francisco, and Johns Hopkins University in Baltimore injected an ...

Now, a leading expert on human gene engineering has warned of what might happen if these technologies are not brought under ...

A study of human tumor cells implanted in mice from the MacPherson Lab at Fred Hutch describes a new way to screen for the ...

In this valuable study, the authors demonstrate that TCF7L2 plays a role in the pathogenesis of cachexia in a mouse model of GI cancer. The results are solid, although future studies will need further ...

In a fascinating turn of science and narrative, small mice have assisted scientists to go back in time. By inserting a human-specific gene into their genetic code, scientists potentially opened up ...

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...

Methods: We performed genome-scale CRISPR/Cas9 knockout screening in ovarian cancer cell lines treated with CDDP, erastin, and a combination of elesclomol and copper (ES+Cu), identifying genes ...

1997; Peier et al., 2002). In particular, genetically modified knockout (KO) mice models have emerged as powerful tools to explore TRP channel functions in cardiac tissue, allowing for precise ...

Myeloid-specific Nod1-knockout (KO) mice were generated by crossing ... and also reported on the Jackson Lab website that insertion of Cre in the Lyz2Cre mouse deletes the endogenous gene essential ...