Female mice that lack the fucose mutarotase (FucM) gene refuse to let males mount ... He said, "The FucM knockout mice displayed drastically reduced sexual receptivity, although pregnancy after ...

To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. This may be done by deleting portions of the gene's DNA sequence to make it nonfunctional ...

Discover how researchers at the University of Pretoria have identified a gene that may transform our understanding of obesity ...

6). The predominant use of gene targeting is to generate mice with loss-of-function mutations, so-called 'knockout mice'. To date, thousands of mouse genes have been disrupted by gene targeting 7,8.

Gene knockout mice exist for about 75% of the corresponding genes in the human genome, Lloyd said. The new KOMP2 awards and collaborative efforts by other IMPC members over the next five years will ...

The goal of the consortium is to identify a function for every gene in the mouse genome, by creating lines of "knockout" mice that lack a single specific gene and screening them for their effects.

Both gene knockout and knock-in models are powerful tools widely used in biomedical research to gain important insights into ...

Not having the gene relates to greater endurance in the knockout mice that were studied. The investigators also showed that the gene is linked to Olympic-level athletes in endurance sports such as ...

Adult animals were given either a control solution or a single dose of the treatment before the gene for PKP2 was knocked out. The mice that received the therapy did not go on to develop ...

Scientists have used CRISPR technology to edit out a lung-disease–causing gene while mice were in utero, rescuing the function of the lung and not affecting other organs, they reported on Wednesday ...

to knockout and characterize all protein-coding genes in the mouse genome. Knocking out the activity of a gene provides valuable clues about what that gene normally does. However, creating and ...