Gene knockout approaches completely ablate gene expression at the DNA level. 3 Researchers can accomplish this by using genome editing tools, such as zinc finger nucleases (ZFN), transcription ...

Both gene knockout and knock-in models are powerful tools widely used in biomedical research to gain important insights into ...

Researchers find that certain antioxidant enzymes, called selenoproteins, significantly contribute to fighting cell aging. The team used a gene knockout mouse model to help them study the effects of ...

Synthego, a leading genome engineering solutions company, today announced the launch of the Gene Knockout Kit v2. This is the only product that leverages a novel bioinformatics- powered multi-guide ...

However, because so many mouse genes are similar to human genes, geneticists can generate knockout mice in which the mouse counterpart of a human gene of interest is deleted or disrupted.

To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. This may be done by deleting portions of the gene's DNA sequence to make it nonfunctional ...

Houston Methodist researchers identified a key protein as a potential therapeutic target for stopping the body’s immune system from mistakenly attacking itself, offering new hope for treating ...

EditCo Bio, a leader in cutting-edge genetic engineering and cellular model solutions, today announced the launch of XDel Knockout Cells, an innovative product designed to revolutionize the field of ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...