GenAI offers a realistic path forward in tackling previously undruggable targets, with the potential to reshape the entire ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Here, we discover lysophospholipids as endogenous pannexin activators, using activity-guided fractionation of mouse tissue extracts combined with untargeted metabolomics and electrophysiology. We show ...

A research team from the Qingdao Institute of Bioenergy and Bioprocess Technology of the Chinese Academy of Sciences, along with collaborators, has introduced a novel membrane design that mimics ...

Isolating GPCRs for structural characterisation is challenging as they are membrane bound, often losing their natural structure and function when isolated. Isolating GPCRs for structural ...

Lambskin condoms, sometimes also known as natural condoms or natural membrane condoms, are a type of external condom made from the intestines of lambs and sometimes sheep. While lambskin condoms are ...

The GPCR superfamily consists of approximately 800 membrane proteins, sharing a common evolutionary origin and coupling primarily to intracellular transducers like G proteins and arrestins. These ...

Cell membrane proteins hide secret gateways that ... cellular activity," explains Dr. Jana Selent, coordinator of the GPCR Drug Discovery Research Group within the Biomedical Informatics Research ...

Researchers were able to observe, at atomic scale and in real time, how membrane lipids interact with G protein-coupled receptors (GPCRs) in their natural environment. These interactions reveal ...

Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045 , United States Department of Pharmacology, University of Colorado Anschutz ...

Anchored to the cell membrane, it interacts with specific lipids to regulate cell growth and division. GPCRs are integral membrane proteins that span the entire lipid bilayer and are involved in ...