EpiBiologics, a leader in tissue-selective extracellular protein degradation, today presented the first preclinical data on its EpiTAC bispecific antibody degrader of c-Met, a potential first-in-class ...

In regenerative science, B7-33's potential to influence fibroblast activity and collagen turnover suggests possible implications for tissue repair and wound healing. Given that fibrosis is often a ...

In the study, Wu and team used a community of 30 bacterial strains commonly found in the human gut. They then added 127 G-protein-coupled receptor (GPCR)-targeting drugs individually to the microbial ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The complement system plays crucial roles in ...

School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China ...

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Researchers from the University of Pittsburgh and Yale University in the US showed that gut bacteria metabolises oral drugs that target cellular receptors called GPCRs. Drugs that act on GPCRs ...

The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes ...

Overall, the findings suggest that specific gut bacteria could make GPCR-targeting drugs less effective by transforming them into other compounds. However, Wu cautioned that more research is ...

Researchers have found that gut bacteria can interfere with the effectiveness of over 400 commonly used medications that target GPCRs, cellular receptors involved in treating conditions like ...

NASDAQ GPCR opened at $17.31 on Tuesday. Structure Therapeutics Inc. has a 1 year low of $17.24 and a 1 year high of $62.74. The company has a market capitalization of $992.61 million, a PE ratio ...