AKT, protein kinase B; CDK, cyclin dependent kinase; FoxO1, forkhead box O1; GPCR, G-protein coupled receptor; GSK3β, glycogen synthase kinase 3β; mTORC1/2, mammalian target of rapamycin complex ...

potentially revolutionizing chronic pain treatment and GPCR drug design. Previously, authors have identified GW461484A (GW) as an inhibitor of the kinase Yck2 in the fungal pathogen Candida albicans.

We identify the GPCR kinase GRK3, and to a lesser extent GRK2, but not GRK4, GRK5, and GRK6, to be recruited to chemokine-stimulated ACKR4. We show that GRK3 recruitment proceded the recruitment of ...

Although eight systems were provided in this dataset, we only selected cyclin-dependent kinase 2 (CDK2), Tyrosine kinase 2 (TYK2 ... GPBAR and OX1 belong to G protein-coupled receptor (GPCR) ...

A recent study published in Engineering delves into the complex mechanisms of drug addiction, highlighting the crucial role of astrocytic G protein-coupled receptors (GPCRs). This research offers ...

Herpesvirus infection may contribute to Alzheimer’s disease through transposable element activation and neuroinflammation.

Our lab is dedicated to uncovering how genetic variations shape protein structure, function, and cellular signaling, ultimately influencing drug responsiveness. By exploring the dynamic nature of ...

The heart is a highly sex-biased organ, as sex shapes innumerable aspects of heart health and disease. Sex chromosomes and sex hormones —testosterone, progesterone, and estrogen— establish and ...

CUO-Recherche, Centre de recherche du CHU de Québec and Département d’ophtalmologie, Faculté de médecine, and Regroupement stratégique PROTEO, Université Laval, Québec, Québec G1V 0A6, Canada Centro ...

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...